Publication List (in reverse chronological order)
81. Hegyi B, Shimkunas R, Jian Z, Izu LT, Bers DM, Chen-Izu Y. Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel. Proc Natl Acad Sci USA. 2021;118(31):e2108484118. doi: 10.1073/pnas.2108484118. Research article (pdf)
80. Mohammad Ali Kazemi-Lari; Alan S. Wineman; Rafael Shimkunas; Zhong Jian; Bence Hegyi; Leighton Izu; Chen-Izu Y. Viscoelastic Eshelby Inclusion Model and Analysis of the Cell-in-Gel System. International Journal of Engineering Science. Vol.165, 1 Aug. 2021,103489. https://doi.org/10.1016/j.ijengsci.2021.103489 Research article (pdf)
79. Izu L, Shimkunas R, Jian Z, Hegyi B, Kazemi-Lari M, Baker A, Shaw J, Banyasz T, Chen-Izu Y. Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes. Life (Basel). 2021 May 29;11(6):503. doi: 10.3390/life11060503. Research Article (pdf)
78. Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach JK, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu LT, Chen-Izu Y. Mechanical Load Regulates Excitation-Ca 2+ Signaling-Contraction in Cardiomyocyte. Circ Res. 2021 Mar 19;128(6):772-774. doi: 10.1161/CIRCRESAHA.120.318570. Epub 2021 Feb 19. Research Letter (pdf)
77. Hegyi B, Chen-Izu Y, Izu LT, Rajamani S, Belardinelli L, Bers DM, Bányász T. Balance Between Rapid Delayed Rectifier K+ Current and Late Na+ Current on Ventricular Repolarization: An Effective Antiarrhythmic Target? Circ Arrhythm Electrophysiol. 2020 Mar 23. doi: 10.1161/CIRCEP.119.008130. Research Article (pdf)
76. Bers DM, Kohl P, Chen-Izu Y. Mechanics and energetics in cardiac arrhythmias and heart failure. J Physiol. 2020 Apr;598(7):1275-1277. doi: 10.1113/JP279385. Editorial (pdf)
75. Izu LT, Kohl P, Boyden PA, Miura M, Banyasz T, Chiamvimonvat N, Trayanova N, Bers DM, Chen-Izu Y. Mechano-electric and mechano-chemo-transduction in cardiomyocytes. J Physiol. 2019 Dec 2. doi: 10.1113/JP276494. PMID: 31789427 [Review and new perspective]. Research Article (pdf)
74. Hegyi B, Chen-Izu Y, Izu LT, Bányász T. Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and β-adrenergic stimulation. Can J Physiol Pharmacol. 2019 Aug;97(8):773-780. PMID: 31091413. Research Article (pdf)
73. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes. Circulation Arrhythm Electrophysiol. 2019 Mar;12(3):e007061. doi: 10.1161/CIRCEP.118.007061. PMID: 30879336. Research Article (pdf)
72. Hegyi B*, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y*. β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII. J Mol Cell Cardiol. 2018 Oct; 123:168-179. doi: 10.1016/j.yjmcc.2018.09.006. Epub 2018 Sep 18. PMID:30240676. Research Article (pdf)
71. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 Sep 21. pii: jgp.201812119. doi: 10.1085/jgp.201812119. PMID: 30242036. Research Article (pdf)
70. Mohammad Kazemi-Lari, John Shaw, Alan Wineman, Rafael Shimkunas, Leighton Izu, Ye Chen-Izu.VISCOELASTIC ESHELBY ANALYSIS OF CARDIOMYOCYTE CONTRACTION IN THE CELL-IN-GEL SYSTE . Proceedings of the ASME 2018 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. SMASIS 2018 September 10-12, 2018, San Antonio, TX, USA. Research Article (pdf)
69. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N*. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 Mar 16;8(1):4670. doi: 10.1038/s41598-018-22843-3. PMID:29549309. Research Article (pdf)
68. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y*. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 Mar 27;115(13): E3036-E3044 pii: 201718211. doi: 10.1073/pnas.1718211115. PMID: 29531045. Research Article (pdf)
67. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM*. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β- Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 Feb;11(2): e005852. doi: 10.1161/CIRCEP.117.005852. PMID:29437761. Research Article (pdf)
66. Coulibaly Z, Chen-Izu Y, Izu LT. Avoiding phantasms. Cardiovasc Res. 2017 Dec 1;113(14):1703-1704. doi: 10.1093/cvr/cvx195. PMID:29036639. Editorial (pdf)
65. Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN*, Zhang XD. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct;10(10). pii: e005267. doi: 10.1161/CIRCEP.117.005267. PMID:29025768. Research Article (pdf)
64. Hegyi B, Horváth B, Váczi K, Gönczi M, Kistamás K, Ruzsnavszky F, Veress R, Izu LT, Chen-Izu Y, Bányász T, Magyar J, Csernoch L, Nánási PP, Szentandrássy N*. Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization. J Mol Cell Cardiol. 2017 Aug; 109:27-37. Research Article (pdf)
63. Chen‐Izu Y* and LT Izu*. Mechano‐chemo‐transduction in cardiac myocytes. J. Physiol. (2017) Jan 18. doi: 10.1113/JP273101. [Review and New Perspective]. Research Article (pdf)
62. Bers DM, Chen-Izu Y. K+ channels and cardiac electrophysiology. J. Physiol. (2017) Apr 1;595(7):2205-2207. doi: 10.1113/JP274181. Editorial (pdf)
61. Grandi E*, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 Apr 1;595(7):2209-2228. doi:10.1113/JP272864. [Review] Research Article (pdf)
60. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. J. Physiol. 2017 Apr 1;595(7):2229-2252. doi: 10.1113/JP272883. [Review] Research Article (pdf)
59. Leighton Izu, Chen-Izu Y. “Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments” Modern Tools of Biophysics: ISBN 978-1-4939-6713-1 (2017) Springer. Book Chapter (pdf)
58. Chen-Izu Y, Leighton T. Izu, Bence Hegyi, Tamas Banyasz. “Recording of Ionic Currents Under Physiological Conditions: Action Potential-Clamp and ‘Onion Peeling’ Techniques” Modern Tools of Biophysics: ISBN 978-1-4939-6713-1 (2017) Springer. Book Chapter (pdf)